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The Role of Ras Oncogene Mutations in Acute Myeloid Leukemia Patients: A Meta-analysis Based on 2502 Cases

Received: 25 December 2018     Accepted: 15 January 2019     Published: 18 February 2019
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Abstract

Background: the ras oncogene mutations frequently occurred in acute myeloid leukemia (AML), but as a prognostic factor remains inconclusive. Methods: The databases of PubMed, Web of Science, EMBASE, and the Cochrane. 22 eligible studies were included this study and analysis was conducted by Comprehensive Meta-Analysis Version 2 software program. All eligible study’s quality assessment refers to the European Lung Cancer Party quality scale. Results: Combined analysis showed that ras oncogene mutation was a poor impact on survival in AML patients (Hazard ratios (HRs): 1.50, 1.19-1.89, p <0.001). Nras gene mutation was a worse survival marker in AML (HR: 1.97, 95% CI: 1.35-2.89, p <0.001) and Kras gene mutations was no significance (HR: 1.32, 95% CI: 0.83-2.09, p =0.24) by stratified analysis. In the analysis of age bracket, adults with ras gene mutation had an unfavorable survival (HR: 1.55, 95% CI: 1.19-2.21, p =0.01) and children harbored ras gene mutation was not significantly with prognosis (HR: 1.22, 95% CI: 0.97-1.53, p =0.09) in AML. Conclusions: This study indicated that AML patients was poor prognosis especially in adult group with ras oncogene mutation, in which Nras mutation, but not Kras mutation involved in guiding survival.

Published in Advances in Applied Physiology (Volume 3, Issue 2)
DOI 10.11648/j.aap.20180302.11
Page(s) 44-56
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Acute Myeloid Leukemia, AML, Ras, Prognostic

References
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Cite This Article
  • APA Style

    Si Li, Pengbo Zhang, Yong Zhang, Li Wang. (2019). The Role of Ras Oncogene Mutations in Acute Myeloid Leukemia Patients: A Meta-analysis Based on 2502 Cases. Advances in Applied Physiology, 3(2), 44-56. https://doi.org/10.11648/j.aap.20180302.11

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    ACS Style

    Si Li; Pengbo Zhang; Yong Zhang; Li Wang. The Role of Ras Oncogene Mutations in Acute Myeloid Leukemia Patients: A Meta-analysis Based on 2502 Cases. Adv. Appl. Physiol. 2019, 3(2), 44-56. doi: 10.11648/j.aap.20180302.11

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    AMA Style

    Si Li, Pengbo Zhang, Yong Zhang, Li Wang. The Role of Ras Oncogene Mutations in Acute Myeloid Leukemia Patients: A Meta-analysis Based on 2502 Cases. Adv Appl Physiol. 2019;3(2):44-56. doi: 10.11648/j.aap.20180302.11

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  • @article{10.11648/j.aap.20180302.11,
      author = {Si Li and Pengbo Zhang and Yong Zhang and Li Wang},
      title = {The Role of Ras Oncogene Mutations in Acute Myeloid Leukemia Patients: A Meta-analysis Based on 2502 Cases},
      journal = {Advances in Applied Physiology},
      volume = {3},
      number = {2},
      pages = {44-56},
      doi = {10.11648/j.aap.20180302.11},
      url = {https://doi.org/10.11648/j.aap.20180302.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.aap.20180302.11},
      abstract = {Background: the ras oncogene mutations frequently occurred in acute myeloid leukemia (AML), but as a prognostic factor remains inconclusive. Methods: The databases of PubMed, Web of Science, EMBASE, and the Cochrane. 22 eligible studies were included this study and analysis was conducted by Comprehensive Meta-Analysis Version 2 software program. All eligible study’s quality assessment refers to the European Lung Cancer Party quality scale. Results: Combined analysis showed that ras oncogene mutation was a poor impact on survival in AML patients (Hazard ratios (HRs): 1.50, 1.19-1.89, p Nras gene mutation was a worse survival marker in AML (HR: 1.97, 95% CI: 1.35-2.89, p Kras gene mutations was no significance (HR: 1.32, 95% CI: 0.83-2.09, p =0.24) by stratified analysis. In the analysis of age bracket, adults with ras gene mutation had an unfavorable survival (HR: 1.55, 95% CI: 1.19-2.21, p =0.01) and children harbored ras gene mutation was not significantly with prognosis (HR: 1.22, 95% CI: 0.97-1.53, p =0.09) in AML. Conclusions: This study indicated that AML patients was poor prognosis especially in adult group with ras oncogene mutation, in which Nras mutation, but not Kras mutation involved in guiding survival.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - The Role of Ras Oncogene Mutations in Acute Myeloid Leukemia Patients: A Meta-analysis Based on 2502 Cases
    AU  - Si Li
    AU  - Pengbo Zhang
    AU  - Yong Zhang
    AU  - Li Wang
    Y1  - 2019/02/18
    PY  - 2019
    N1  - https://doi.org/10.11648/j.aap.20180302.11
    DO  - 10.11648/j.aap.20180302.11
    T2  - Advances in Applied Physiology
    JF  - Advances in Applied Physiology
    JO  - Advances in Applied Physiology
    SP  - 44
    EP  - 56
    PB  - Science Publishing Group
    SN  - 2471-9714
    UR  - https://doi.org/10.11648/j.aap.20180302.11
    AB  - Background: the ras oncogene mutations frequently occurred in acute myeloid leukemia (AML), but as a prognostic factor remains inconclusive. Methods: The databases of PubMed, Web of Science, EMBASE, and the Cochrane. 22 eligible studies were included this study and analysis was conducted by Comprehensive Meta-Analysis Version 2 software program. All eligible study’s quality assessment refers to the European Lung Cancer Party quality scale. Results: Combined analysis showed that ras oncogene mutation was a poor impact on survival in AML patients (Hazard ratios (HRs): 1.50, 1.19-1.89, p Nras gene mutation was a worse survival marker in AML (HR: 1.97, 95% CI: 1.35-2.89, p Kras gene mutations was no significance (HR: 1.32, 95% CI: 0.83-2.09, p =0.24) by stratified analysis. In the analysis of age bracket, adults with ras gene mutation had an unfavorable survival (HR: 1.55, 95% CI: 1.19-2.21, p =0.01) and children harbored ras gene mutation was not significantly with prognosis (HR: 1.22, 95% CI: 0.97-1.53, p =0.09) in AML. Conclusions: This study indicated that AML patients was poor prognosis especially in adult group with ras oncogene mutation, in which Nras mutation, but not Kras mutation involved in guiding survival.
    VL  - 3
    IS  - 2
    ER  - 

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Author Information
  • Department of Pathology, Kunming Medical University, Kunming, P.R. China

  • Medical Faculty, Kunming University of Science and Technology, Kunming, P.R. China

  • Department of Oncology, First Affiliated Hospital of Kunming Medical University, Kunming, P.R. China

  • Department of Pathology, Yunnan First People’s Hospital, Kunming, P.R. China

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