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The Study of Effect of Amphetamine on Passive Avoidance Learning in Wistar Male Rats

Received: 25 January 2018     Accepted: 16 February 2018     Published: 29 May 2018
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Abstract

Methamphetamine is sometimes prescribed by doctors for specific diseases that with the entering the central nervous system caused by a sudden release of categulamine and particularly dopamine in the brain. It stimulates brain cells, enhancing aggressive mood and increased body movement. The purpose of this study was to investigate, has been the effects of methamphetamine on passive avoidance learning and memory in adult male Wistar rats. Male Wistar rats of rats in the weight range (180-220gr) (N=6) was Divided into healthy group - control group (saline received) and dose received groups (1.5, 3, 5 mg/kg). Half an hour before the test, intraperitoneally injection was done and after the test, every day at specific times for long-term memory test for one week Injection was done. Results have shown that the incidence of passive avoidance between healthy and control groups there was no significant difference but there is a significantly decreased between the control group and the group receiving methamphetamine. Increase learning and short-term memory and reduced long term memory and passive avoidance learning mechanism is probably due to the involvement of the hippocampus in learning and memory consolidation and short term memory convert to long-term memory could potential mechanism of methamphetamine-induced damage to hippocampal neurons, particularly CA1 neurons. Meanwhile, short-term memory-enhancing effects of methamphetamine can result in Increase cortisol is also a short-term strengthens to the memory but in long term it will damage and weaken the memory.

Published in Advances in Applied Physiology (Volume 3, Issue 1)
DOI 10.11648/j.aap.20180301.11
Page(s) 1-7
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Methamphetamine, Passive Avoidance Learning, Male Rat

References
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  • APA Style

    Milad Rezazadeh, Mehdi Ahmadifar, Meysam Ahmadi Manesh. (2018). The Study of Effect of Amphetamine on Passive Avoidance Learning in Wistar Male Rats. Advances in Applied Physiology, 3(1), 1-7. https://doi.org/10.11648/j.aap.20180301.11

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    ACS Style

    Milad Rezazadeh; Mehdi Ahmadifar; Meysam Ahmadi Manesh. The Study of Effect of Amphetamine on Passive Avoidance Learning in Wistar Male Rats. Adv. Appl. Physiol. 2018, 3(1), 1-7. doi: 10.11648/j.aap.20180301.11

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    AMA Style

    Milad Rezazadeh, Mehdi Ahmadifar, Meysam Ahmadi Manesh. The Study of Effect of Amphetamine on Passive Avoidance Learning in Wistar Male Rats. Adv Appl Physiol. 2018;3(1):1-7. doi: 10.11648/j.aap.20180301.11

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  • @article{10.11648/j.aap.20180301.11,
      author = {Milad Rezazadeh and Mehdi Ahmadifar and Meysam Ahmadi Manesh},
      title = {The Study of Effect of Amphetamine on Passive Avoidance Learning in Wistar Male Rats},
      journal = {Advances in Applied Physiology},
      volume = {3},
      number = {1},
      pages = {1-7},
      doi = {10.11648/j.aap.20180301.11},
      url = {https://doi.org/10.11648/j.aap.20180301.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.aap.20180301.11},
      abstract = {Methamphetamine is sometimes prescribed by doctors for specific diseases that with the entering the central nervous system caused by a sudden release of categulamine and particularly dopamine in the brain. It stimulates brain cells, enhancing aggressive mood and increased body movement. The purpose of this study was to investigate, has been the effects of methamphetamine on passive avoidance learning and memory in adult male Wistar rats. Male Wistar rats of rats in the weight range (180-220gr) (N=6) was Divided into healthy group - control group (saline received) and dose received groups (1.5, 3, 5 mg/kg). Half an hour before the test, intraperitoneally injection was done and after the test, every day at specific times for long-term memory test for one week Injection was done. Results have shown that the incidence of passive avoidance between healthy and control groups there was no significant difference but there is a significantly decreased between the control group and the group receiving methamphetamine. Increase learning and short-term memory and reduced long term memory and passive avoidance learning mechanism is probably due to the involvement of the hippocampus in learning and memory consolidation and short term memory convert to long-term memory could potential mechanism of methamphetamine-induced damage to hippocampal neurons, particularly CA1 neurons. Meanwhile, short-term memory-enhancing effects of methamphetamine can result in Increase cortisol is also a short-term strengthens to the memory but in long term it will damage and weaken the memory.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - The Study of Effect of Amphetamine on Passive Avoidance Learning in Wistar Male Rats
    AU  - Milad Rezazadeh
    AU  - Mehdi Ahmadifar
    AU  - Meysam Ahmadi Manesh
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    PY  - 2018
    N1  - https://doi.org/10.11648/j.aap.20180301.11
    DO  - 10.11648/j.aap.20180301.11
    T2  - Advances in Applied Physiology
    JF  - Advances in Applied Physiology
    JO  - Advances in Applied Physiology
    SP  - 1
    EP  - 7
    PB  - Science Publishing Group
    SN  - 2471-9714
    UR  - https://doi.org/10.11648/j.aap.20180301.11
    AB  - Methamphetamine is sometimes prescribed by doctors for specific diseases that with the entering the central nervous system caused by a sudden release of categulamine and particularly dopamine in the brain. It stimulates brain cells, enhancing aggressive mood and increased body movement. The purpose of this study was to investigate, has been the effects of methamphetamine on passive avoidance learning and memory in adult male Wistar rats. Male Wistar rats of rats in the weight range (180-220gr) (N=6) was Divided into healthy group - control group (saline received) and dose received groups (1.5, 3, 5 mg/kg). Half an hour before the test, intraperitoneally injection was done and after the test, every day at specific times for long-term memory test for one week Injection was done. Results have shown that the incidence of passive avoidance between healthy and control groups there was no significant difference but there is a significantly decreased between the control group and the group receiving methamphetamine. Increase learning and short-term memory and reduced long term memory and passive avoidance learning mechanism is probably due to the involvement of the hippocampus in learning and memory consolidation and short term memory convert to long-term memory could potential mechanism of methamphetamine-induced damage to hippocampal neurons, particularly CA1 neurons. Meanwhile, short-term memory-enhancing effects of methamphetamine can result in Increase cortisol is also a short-term strengthens to the memory but in long term it will damage and weaken the memory.
    VL  - 3
    IS  - 1
    ER  - 

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Author Information
  • Department of Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran

  • Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran

  • Department of Animal Sciences, Faculty of Agriculture and Natural Resources, Gonbad Kavous University, Gonbad-e Kavus, Iran

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